Other Drugs Used for Indigestion Relief

Aside from Alminum Hydroxide and Calcium Carbonate, there are other drugs that were proven to offer immediate indigestion relief. Here is a brief drug study of Magnesium Oxide and Simethicone.

Magnesium Oxide

Magnesium oxide has brand names including Mag ox 400, Maox, and Uromag. It is under the pharmacological class of magnesium salt and pregnancy risk category B. It is available in capsules and tablets. It is indicated for patients with acid indigestion and those who need oral replacement therapy in mild hypomagnesemia. Its mode of action is the reduction of total acid load in the gastrointestinal tract, elevation of gastric pH to reduce pepsin activity, strengthening of gastric mucosal barrier, and increasing esophageal sphincter tone.

Adverse reactions include diarrhea, abdominal pain, nausea and hypermagnesmia. It may affect the magnesium level so inform the doctor regarding it for lab tests results. It is contraindicated to patients with severe kidney disease. It must be used cautiously in patients with mild renal impairment because it may aggravate the condition.

Some considerations when giving the drug include monitoring the magnesium level closely. Signs of increasing magnesium levels are hypotension, nausea, vomiting, depressed reflexes, respiratory depression, and coma. If diarrhea occurs, use a different drug.

Patient Teaching

Advise the patient not to take the drug indiscriminately or to switch anatacids without prescription. Urge patient to report signs of gastrointestinal bleeding like melena or black tarry stools and hemoptysis or blood tinged vomitus.


Simethicone has brand names of Flatulex, Gas X, and Maalox. It is under the pharmacological class of polydimethylsiloxanes and pregnancy risk category C. It is available in capsules, tablets, drops, and chewable tablets. It is indicated for patients with flatulence problems and functional gastric bloating. Its mode of action is that it disperses or prevents formation of mucus surrounded gas pockets in the gastrointestinal tract.

Adverse reactions are belching and flatus. It has no known drug to drug interactions, as well as significant effect on laboratory test results. It is contraindicated in patients hypersensitive to drug and infants with colic. Simethicone does not prevent gas formation and must not be confused with cimetidine since they sound alike.

Patient Teaching

Tell the patient to chew the tablet thoroughly before swallowing to facilitate better absorption. If taken by an infant, inform the parents that drops may be mixed with cool water, infant formula, or juice. Advise patient that changing positions often and walking will help greatly in the passage of flatus, thus providing indigestion relief.